Closed Restricted Access Barrier System - cRABS

What is the Closed Restricted Access Barrier System ?

The Closed Restricted Access Barrier System (cRABS) designed by Shanghai QUALIA is a state-of-the-art aseptic processing solution that creates a highly controlled, enclosed environment to protect sterile or minimally toxic product production. The system maintains a positive pressure regime, employing advanced air filtration systems that deliver air cleanliness at high levels, in accordance with air quality standards. The integrity of the sterile environment is preserved by keeping the system’s doors sealed during operation.

Features of Shanghai QUALIA's Closed Restricted Access Barrier System (cRABS)

Air Filtration: HEPA filters installed in QUALIA’s cRABS ensure maintenance of ISO Class 5 air purity. The airflow is expertly engineered to prevent contamination and sustain a pristine environment within the system.
Physical Barrier: A solid barrier prevents direct operator-product contact, safeguarding product sterility.
Controlled Environment: All critical environmental parameters, such as temperature, humidity, and pressure, are meticulously managed to suit sensitive pharmaceutical handling.
Design Versatility: The systems are inherently versatile, designed to be adapted to varied production needs and facility configurations. They can include features like integrated glove ports, state-of-the-art LED illumination, and comprehensive control systems for precise monitoring and automation.

Different Types of Closed Restricted Access Barrier System (cRABS)

Shanghai QUALIA’s cRABS is available in multiple configurations to cater to diverse operation requirements, including:

Passive cRABS: These utilize the facility’s existing HVAC airflow, leveraging centrally supplied HEPA-filtered air for maintaining a clean atmosphere.
Active cRABS: Featuring an autonomous air handling unit, this variant enables complete environmental control and may include advanced options for automated decontamination and specialized material transfer systems.

Barry Liu

Hi, I’m Barry Liu, a Sales Engineer at QUALIA. I’ve worked with laboratory biosafety equipment since 2010 and have conducted more than 200 on-site biosafety cabinet certifications. I write about evaluating containment filtration, vaporized hydrogen peroxide (VHP) generators and cycle validation, and effluent decontamination systems.

Related News

Minimizing Contamination Risk in Test Isolators

Reduce contamination risks in sterility test isolators. Implement best practices for aseptic testing in pharmaceutical QC.

BSL-4 Effluent Treatment: BioSafe’s Ultimate EDS

Discover BioSafe’s EDS solutions for BSL-4 facilities. Uncompromising safety for the highest level of biocontainment.

Portable VHP Hydrogen Peroxide Generator Guide | Type II vs Type III Comparison

Portable VHP generators offer flexible sterilization for heat-sensitive and complex pharmaceutical equipment, reducing contamination risks and production delays.

Bio-Safety Isolation Dampers: Key Features and Benefits by QUALIA

In the realm of biosecurity and containment, the Bio-Safety Isolation Damper by QUALIA stands out as a crucial component for managing airflow and preventing the leakage of pathogenic microorganisms. Here’s a detailed look at its features and benefits. What is a Bio-Safety Isolation Damper? A Bio-Safety Isolation Damper is designed to modulate or halt airflow within a system, thereby mitigating the risk of pathogenic microorganism leakage. These dampers are available in both manual and electric types, depending on the actuation mechanism. Key Features of QUALIA Bio-Safety Isolation Dampers Air Tightness At a pressure of ±5000Pa, the leakage rate does not exceed 0.25% of the net volume per hour. Pressure Resistance The valve box can withstand a pressure of -5000Pa for 60 minutes without permanent structural

7 Key Benefits of Portable Decontamination in 2025

Discover the advantages of portable decontamination systems. Learn how they enhance flexibility and efficiency in sterilization processes.

How to Set Up VHP Isolator Decontamination for Aseptic Processing

Setting up VHP isolator decontamination for aseptic processing requires matching the generator output to isolator volume, configuring injection and aeration ports, and validating cycle reproducibility. This article provides a step-by-step guide for configuring VHP isolator decontamination that meets aseptic processing compliance under EU GMP Annex 1.